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The micro-distribution mapping of iron in the rat brain after nanoparticle intranasal exposure was achieved by synchrotron radiation micro-beam X-ray fluorescence (SR-μXRF) at the Beijing Synchrotron Radiation Facility (BSRF) 4W1B beamline, with space resolution of several micrometer and detection limit of ng/g range. The incident beam was focused approximately 20 × 30 μm by a Pb collimator with two cross-slice...

Recently, arsenite (As) have been applied to treat the acute promyelocytic leukemia (APL) successfully. Further research revealed that the apoptotic effects of arsenic are not restricted to APL cells but also can be observed in other malignant cells in vitro. There are at least three different molecular mechanisms are proposed but not uniform. Note that all these molecular mechanisms are contrary with each other ...

The rove beetles (Insecta, Coleoptera, Staphylinidae) are mainly predators. They use the mandible of their mouthparts to bite food. According to previous morphological studies, three different types of mandibles and heads can be recognized. Presently, the relationship of the head shapes and the robustness of mandibles in rove beetles as well as in other beetle groups is a matter of debate. The group Molecular syst...

The 5′-cap structure is a distinct feature of eukaryotic mRNAs, and eukaryotic viruses generally modify the 5′-end of viral RNAs to mimic cellular mRNA structure, which is important for RNA stability, protein translation and viral immune escape. SARS coronavirus (SARS-CoV) encodes two S-adenosyl-L-methionine (SAM)-dependent methyltransferases (MTase) which sequentially methylate the RNA cap at guanosine-N7 and r...

ATR-X (alpha-thalassemia/mental retardation, X-linked) syndrome is a human congenital disease whose clinical manifestations are α-thalassemia and mental retardation. Approximately 50% of the missense mutations in affected persons are clustered in the ADD (ATRX-DNMT3-DNMT3) domain of the syndrome’s key gene ATRX. However, the function of ATRX ADD (ADDATRX) domain has remained elusive. In collaboration with Dr. Y...

Box H/ACA RNA-protein complexes (H/ACA RNPs) are ancient molecular machines conserved from archaea to eukaryotes that mediate pseudouridine synthesis, eukaryotic ribosome biogenesis and vertebrate telomere formation. Although studies of archaeal H/ACA RNP has led to a rather detailed understanding of its structure and mechanism of action, the assembly and architecture of eukaryotic H/ACA RNP remain unclear. The la...
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