Scientists from the Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety at
IHEP found that nuclear analytical techniques could be applied to nanotoxicology research. The scientific results entitled Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology were published on Chemical Society Reviews (Chunying Chen, Yu-Feng Li, Ying Qu, Zhifang Chai and Yuliang Zhao, Chem. Soc. Res., Article ASAP, DOI: 10.1039/c3cs60111k).
Systematic platform using integrated advanced nuclear techniques for nanotoxicology
In the paper, scientists present a comprehensive overview of nuclear analytical techniques applied to the physicochemical characterization of nanomaterials, structural analysis of bio-nano interactions, visualization of nanomaterials in vitro, quantification of bio-distribution, bio-accumulation, and
transformation of nanomaterials in vivo. As important complementary tools, optical imaging technologies are also highlighted. Future directions regarding advanced nuclear analytical approaches for nanotoxicology are also discussed.
Because of their advantages of absolute quantification, high sensitivity, excellent accuracy and precision, low matrix effects and non-destructiveness, nuclear analytical techniques have been playing important roles in the study of nanotoxicology.
It is believed that the rapid development of advanced light source-based techniques will enable new high throughput screening techniques and provide high sensitivity with low detection limits, which are required for the distribution, imaging, and structural analysis of nanomaterials, and the molecular information of biomarkers for all aspects of nanotoxicology.